Listed in Issue 286


LM OLIVEIRA and COLLEAGUES,  1 Laboratory of Dermatology and Immunodeficiencies, LIM-56, Department of Dermatology, School of Medicine, University of São Paulo, Institute of Tropical Medicine of São Paulo, São Paulo, SP, Brazil review the effect of retinoic acid (RA) on innate and adaptive immunity with a special emphasis on inflammatory status.


Vitamin A metabolite retinoic acid (RA) plays important roles in cell growth, differentiation, organogenesis, and reproduction and a key role in mucosal immune responses.


RA promotes dendritic cells to express CD103 and to produce RA, enhances the differentiation of Foxp3+ inducible regulatory T cells, and induces gut-homing specificity in T cells.


Although vitamin A is crucial for maintaining homeostasis at the intestinal barrier and equilibrating immunity and tolerance, including gut dysbiosis, retinoids perform a wide variety of functions in many settings, such as the central nervous system, skin ageing, allergic airway diseases, cancer prevention and therapy, and metabolic diseases.


The mechanism of RA is interesting to explore as both a mucosal adjuvant and a combination therapy with other effective agents. Here, we review the effect of RA on innate and adaptive immunity with a special emphasis on inflammatory status.


Luana de Mendonça Oliveira  1 , Franciane Mouradian Emidio Teixeira  1 , Maria Notomi Sato  1. Impact of Retinoic Acid on Immune Cells and Inflammatory Diseases Mediators Inflamm.; 2018:3067126. doi: 10.1155/2018/3067126. eCollection 2018. Aug 9 2018.

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