Research: LIU and COLLEAGUES,

Listed in Issue 228

Abstract

LIU and COLLEAGUES, (1)The Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Science, Nagoya University, Nagoya, 464-8601, Japan, xueboliu@nwsuaf.edu.cn explored the possibility that reactive lipid hydroperoxides (LOOHs) species derived from DHA/AA lipid peroxidation may modify dopamine to form amide-linkage dopamine adducts, which might be related to aetiology of Parkinson's diseases

Background

Dopamine is the endogenous neurotransmitter produced by nigral neurons. Dopamine loss can trigger not only prominent secondary morphological changes, but also changes in the density and sensitivity of dopamine receptors; therefore, it is a sign of Parkinson’s Disease (PD) development.

Methodology

The reasons for dopamine loss are attributed to dopamine's molecular instability due to it is a member of catecholamine family, whose catechol structure contributes to high oxidative stress through enzymatic and non-enzymatic oxidation.

Results

Oxidative stress in the brain easily leads to the lipid peroxidation reaction due to a high concentration of polyunsaturated fatty acids (PUFA), such as docosahexaenoic acid (DHA, C22:6/ω-3) and arachidonic acid (AA, C18:4/ω-6). Recent studies have shown that lipid hydroperoxides, the primary peroxidative products, could non-specifically react with primary amino groups to form N-acyl-type (amide-linkage) adducts.

Conclusion

Therefore, based on the NH2-teminals in dopamine's structure, the aims of this chapter are to describes the possibility that reactive LOOH species derived from DHA/AA lipid peroxidation may modify dopamine to form amide-linkage dopamine adducts, which might be related to etiology of Parkinson's diseases.

References

Liu X(1), Yamada N, Osawa T. Amide-type adduct of dopamine - plausible cause of Parkinson diseases.  Subcell Biochem 77:49-60. doi: 10.1007/978-94-007-7920-4_4. 2014.

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