Research: LARRIEU and colleagues,

Listed in Issue 107


LARRIEU and colleagues, Epidemiology Research Unit, Institut National de la Sante et de la Recherche Medicale (INSERM) U593, Bordeaux cedex, France,, have researched nutritional factors and the risk of dementia.


The aim of the study was to present a summary of the results obtained in the PAQUID study on wine consumption, fish and seafood consumption and vitamin A and E plasma concentrations in older people.


The base of the study was the PAQUID (Personnes Agees QUID) cohort, an epidemiological study on cognitive and functional aging after 65 years in France. The relationship between nutritional factors and risk of incident dementia was measured using logistic regression or Cox proportional hazards models on different subsamples of the cohort.


Among 2950 subjects studied, moderate drinkers had a decreased risk of developing dementia in the subsequent 8 years as compared to non-drinkers (relative risk 0.56). Those who ate fish or seafood at least once a week had a significantly reduced risk of developing dementia (relative risk 0.66). In addition, the risk for dementia was greatly increased for the lowest concentrations of vitamin E compared to the highest ones (odds ratio 2.54).


These results are in agreement with a possible protective role of a diet rich in polyunsaturated fatty acids and antioxidants against dementia.


Larrieu S, Letenneur L, Helmer C, Dartigues JF, Barberger-Gateau P. Nutritional factors and risk of incident dementia in the PAQUID longitudinal cohort. Journal of Nutrition, Health & Aging. 8(3): 150-4, 2004.

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