Research: KIM and co-workers,

Listed in Issue 152

Abstract

KIM and co-workers, Department of Dermato-Immunology, College of Medicine, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul, South Korea, have found that a compound from ginger prevents oxidative damage from UV radiation.

Background

[6]-Gingerol, a naturally occurring plant phenol, is one of the major components of fresh ginger (Zingiber officinale) and has various pharmacological effects. The aim of this study was to describe its novel anti-oxidant, anti-apoptotic, and anti-inflammatory activities in vitro and in vivo.

Methodology

Laboratory study involving cells in culture and hairless mice.

Results

In vitro, pre-treatment with [6]-gingerol reduced UVB-induced intracellular reactive oxygen species levels, activation of caspase, and Fas expression, all markers of oxidative damage. It also reduced UVB-induced expression of the enzyme cyclo-oxygenase-2 which is involved in inflammatory responses. Translocation of NF-kappaB from cytosol to nucleus in HaCaT cells was inhibited by [6]-gingerol via suppression of its phosphorylation. Topical application of [6]-gingerol (30 microM) prior to UVB irradiation (5 kJ/m(2)) of hairless mice also inhibited the production of cyclooxygenase-2, as well as NF-kappaB translocation.

Conclusion

These results suggest that [6]-gingerol could be an effective therapeutic agent providing protection against UV radiation-induced skin disorders.

References

Kim JK, Kim Y, Na KM, Surh YJ, Kim TY. [6]-Gingerol prevents UVB-induced ROS production and COX-2 expression in vitro and in vivo. Free Radical Research 41 (5): 603-614, May 2007.

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