Research: KATAJA-TUOMOLA and COLLEAGUES,

Listed in Issue 200

Abstract

KATAJA-TUOMOLA and COLLEAGUES, Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland. merja.kataja-tuomola@thl.fi  investigated the association of dietary antioxidants with incident type 2 diabetes in the alpha-Tocopherol, beta-Carotene Cancer Prevention Study cohort.

Background

Oxidative stress may induce insulin resistance in peripheral tissues and impair insulin secretion from pancreatic beta-cells. Antioxidants are suggested to decrease the risk of diabetes through reduction of oxidative stress. However, only a few studies exist on dietary antioxidants and the risk of type 2 diabetes. The authors investigated the association of dietary antioxidants with incident type 2 diabetes in the alpha-Tocopherol, beta-Carotene Cancer Prevention Study cohort.

Methodology

The study cohort included 29,133 male smokers aged 50-69 years. During a median follow-up of 10.2 years 660 incident cases of diabetes were observed among the 25,505 men with a completed baseline food frequency questionnaire.

Results

Dietary alpha-tocopherol, beta-tocopherol and beta-tocotrienol were positively associated with the risk of diabetes when adjusted for age and supplementation (relative risk (RR) 1.17 (95% confidence interval (CI) 0.91-1.51) P for trend 0.02; RR 1.31 (95% CI 1.02-1.68) P for trend 0.01; RR 1.28 (95% CI 1.00-1.63) P for trend 0.01, respectively), but the association disappeared after multivariate adjustment (RR 0.92 (95% CI 0.71-1.19) P for trend 0.97; RR 1.06 (95% CI 0.82-1.36) P for trend 0.48; RR 1.04 (95% CI 0.80-1.35) P for trend 0.46, respectively). Other tocopherols and tocotrienols as well as vitamin C, carotenoids, flavonols and flavones had no association with risk of diabetes.

Conclusion

Dietary antioxidants were not associated with a decreased risk of incident diabetes in middle-aged male smokers.

References

Kataja-Tuomola MK, Kontto JP, Mannisto S, Albanes D, Virtamo J. Intake of antioxidants and risk of type 2 diabetes in a cohort of male smokers. European Journal of Clinical Nutrition. 65(5): 590-7. May 2011.

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