Research: JAVANBAKHT and COLLEAGUES,

Listed in Issue 196

Abstract

JAVANBAKHT and COLLEAGUES, Department of Nutrition and Biochemistry, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran conducted a randomized, double-blind, placebo-controlled trial to evaluate the effects of vitamins D and E supplementation on the clinical manifestation of atopic dermatitis.

Background

Atopic dermatitis is a chronically relapsing, highly pruritic and inflammatory skin disease. This study was done to assess the effects of vitamins D and E supplementation on the clinical manifestation of atopic dermatitis.

Methodology

Forty-five atopic dermatitis patients were included in a randomized, double-blind, placebo-controlled trial. They were randomly divided into four groups and treated for 60 days: group P (n = 11), vitamins D and E placebos; group D (n = 12), 1600 IU vitamin D(3) plus vitamin E placebo; group E (n = 11), 600 IU synthetic all-rac-alpha-tocopherol plus vitamin D placebo; and group DE (n = 11), 1600 IU vitamin D(3) plus 600 IU synthetic all-rac-alpha-tocopherol. Serum 25(OH) vitamin D and plasma alpha-tocopherol were determined before and after the trial. The clinical improvement was evaluated with SCORing Atopic Dermatitis (SCORAD). Data were analyzed by analysis of variance (ANOVA) and Kruskal-Wallis tests.

Results

SCORAD was reduced after 60 days in groups D, E and DE by 34.8%, 35.7% and 64.3%, respectively (p = 0.004). Objective SCORAD also showed significant improvement. There was a positive correlation between SCORAD and intensity, objective, subjective and extent (p < 0.001). We found a significant negative association between plasma alpha-tocopherol and SCORAD, intensity, objective and extent (p = 0.02).

Conclusion

This study supports the contributing and beneficial effects of vitamins D and E in the treatment of atopic dermatitis.

References

Javanbakht MH, Keshavarz SA, Djalali M, Siassi F, Eshraghian MR, Firooz A, Seirafi H, Ehsani AH, Chamari M and Mirshafiey A. Randomized controlled trial using vitamins E and D supplementation in atopic dermatitis. Source Journal of Dermatological Treatment. 22(3):144-50. Jun 2011.

Munro Hall Clinic 2019

IJCA 2018 New Skyscraper

Scientific and Medical Network 2

Cycle India 2020

Walk on the Wide Side Trek Kenya 2020

Big Heart Bike Ride South Africa 2020

top of the page