Positive Health Online

Abstract

KHOSROSHAHI and COLLEAGUES,  (1)Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. (2)Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.(3)Student Research Committee, Tabriz University of Medical Sciences, Tabriz, the Islamic Republic of Iran.(4)Department of Clinical Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, the Islamic Republic of Iran.(5)Cabrini Monash Department of Surgery, Cabrini Hospital, Melbourne, VIC, Australia.(6)Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia investigated the dose-dependent effects of omega-3 fatty acids supplementation on inflammatory factors in cancer patients

 

Background

Until now, no study evaluated the impact of optimum intake of omega-3 fatty acids on inflammatory factors. We aimed to investigate the dose-dependent effects of omega-3 fatty acids supplementation on inflammatory factors in cancer patients.

Methodology

PubMed, Scopus and ISI Web of Science were searched until July 2022 to find randomized controlled trials (RCTs) for examining the efficacy of omega-3 fatty acids on inflammatory factors. Our primary outcomes were interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), and albumin.

Results

The results of 33 trials (2068 participants) revealed that each 1 g/day omega-3 fatty acids (oral/enteral) significantly reduced IL-6 (SMD: -1.17 pg/ml; 95% CI: -1.78, -0.55; p < 0.001; GRADE = moderate), and TNF-α (SMD: -2.15 pg/ml; 95% CI: -3.14, -1.16; p < 0.001; GRADE = very low). Moreover, each 0.5 g/kg/day omega-3 fatty acids (parenteral) significantly reduced TNF-α (SMD: -1.11 pg/ml; 95% CI: -2.02, -0.19; p = 0.017; GRADE = low).

Conclusion

With moderate and very low evidence certainty, each 1 g/day of omega-3 fatty acids supplementation (oral/enteral) has a beneficial effect on IL-6 and TNF-α. Each 0.5 g/kg/day omega-3 fatty acids (parenteral) could also exert a favourable impact on TNF-α, but the certainty of the evidence was low.

References

Amiri Khosroshahi R(1), Heidari Seyedmahalle M(2), Zeraattalab-Motlagh S(2), Fakhr L(3)(4), Wilkins S(5), Mohammadi H(1)(6). The Effects of Omega-3 Fatty Acids Supplementation on Inflammatory Factors in Cancer Patients: A Systematic Review and Dose-Response Meta-Analysis of Randomized Clinical Trials. Nutr Cancer. 76(1):1-16. . Epub Dec 27 2023 . 2024; doi: 10.1080/01635581.2023.2274135