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Research: HARTMAN and colleagues,
Listed in Issue 39
Abstract
HARTMAN and colleagues, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda Maryland 20892-7326 USA evaluated the association between prostate cancer and baseline vitamin E and selenium .
Background
Methodology
The authors used the trial-based cohort of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (n = 29,133). The data were analysed using multivariate Cox proportional hazards models which were adjusted for intervention group, benign prostatic hyperplasia, age, smoking and urban residence.
Results
During up to 9 years of follow-up, 317 men developed incident prostate cancer. There were no significant associations between baseline serum alpha-tocopherol, dietary vitamin E or selenium and prostate cancer overall. The associations between prostate cancer and vitamin E and some of the baseline dietary tocopherols differed significantly by alpha-tocopherol intervention status, with the suggestion of a protective effect for total vitamin E among those who received the alpha-tocopherol intervention (relative risk was 1.00, 0.68, 0.80, and 0.52 for increasing quartiles; P = 0.07).
Conclusion
References
Hartman TJ et al. The association between baseline vitamin E, selenium, and prostate cancer in the alpha-tocopherol, beta-carotene cancer prevention study. Cancer Epidemiol Biomarkers Prev 7(4): 335-40 Apr 1998.
