Research: HAN and COLLEAGUES,

Listed in Issue 208

Abstract

HAN and COLLEAGUES, Institution Department of Toxicology, College of Pharmacy, Chungnam National University, Daejeon 305-764, South Korea investigated the anti-allergy potential of P. eryngii extract (PEE) in antigen-stimulated RBL-2H3 mast cells.

Background

Pleurotus eryngii is an edible mushroom native to Europe, the Middle East, and North Africa, and is also grown in parts of Asia.

Methodology

The present study investigated the anti-allergy potential of P. eryngii extract (PEE) in antigen-stimulated RBL-2H3 mast cells.

Results

PEE inhibited allergy markers, including release of hexosaminidase and histamine, in antigen-sensitized RBL-2H3 cells. PEE also suppressed the expression and production of interleukin-4 and reduced antigen-induced NFAT and NF-kappaB transcriptional activity in antigen-sensitized mast cells. Moreover, PEE decreased the levels of proinflammatory cytokines and COX-2 and iNOS expression in antigen-sensitized mast cells. Finally, PEE suppressed antigen-induced signal protein phosphorylation of Lyn, PLCgamma2, PKC, Akt, and MAP kinases.

Conclusion

Taken together, these results suggest that P. eryngii extract may provide insight into the prevention and treatment of allergic and inflammatory diseases.

References

Han EH, Hwang YP, Kim HG, Choi JH, Im JH, Yang JH, Lee HU, Chun SS, Chung YC and Jeong HG. Inhibitory effect of Pleurotus eryngii extracts on the activities of allergic mediators in antigen-stimulated mast cells. Source Food & Chemical Toxicology. 49(6):1416-25. Jun 2011.

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