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Research: HALLIWEL L, Department of
Listed in Issue 89
Abstract
HALLIWEL L, Department of Biochemistry, Faculty of Medicine, National University of Singapore, MD 7 #03-15, 8 Medical Drive, Singapore 117597, bchbh@nus.edu.sg, has reviewed (88 references) vitamin E and the treatment and prevention of diabetes.
Background
Diabetes is accompanied by oxidative stress, especially seen as lipid peroxidation, due to increased oxygen free radical production. This results in part from hyperglycaemia, but it may also precede and accelerate the development of type 2 diabetes and its complications.
Methodology
Results
Epidemiological evidence suggests that low vitamin E intake is a risk factor for the development of type 2 diabetes, and small scale intervention studies have demonstrated a benefit of vitamin E for epithelial function, retinal blood flow, and renal dysfunction (all common sequelae of type 2 diabetes). Animal studies also support the usefulness of vitamin E.
Conclusion
The available evidence suggests that a major double-blinded controlled clinical trial of antioxidants in the prevention and treatment of type 2 diabetes should be undertaken in order to develop strategies to delay the onset and ameliorate the sequelae of this disease.
References
Halliwell B. Vitamin E and the treatment and prevention of diabetes: a case for a controlled clinical trial. Singapore Medical Journal 43 (9): 479-484, Sep 2002.
