Research: FORSTER and COLLEAGUES,

Listed in Issue 248

Abstract

FORSTER and COLLEAGUES,  (1)Department of Environmental and Radiological Health Sciences, Colorado State University, 1681 Campus Delivery Fort Collins, CO 80523, United States studied and analyzed seven rice bran varieties for growth inhibition of human colorectal cancer (CRC) cells.

Background

Rice bran chemical profiles differ across rice varieties and have not yet been analysed for differential chemopreventive bioactivity.

Methodology

A diverse panel of seven rice bran varieties was analysed for growth inhibition of human colorectal cancer (CRC) cells.

Results

Inhibition varied from 0% to 99%, depending on the variety of bran used. Across varieties, total lipid content ranged 5-16%, individual fatty acids had 1.4- to 1.9-fold differences, vitamin E isoforms (α-, γ-, δ-tocotrienols, and tocopherols) showed 1.3- to 15.2-fold differences, and differences in γ-oryzanol and total phenolics ranged between 100-275ng/mg and 57-146ngGAE/mg, respectively. Spearman correlation analysis was used to identify bioactive compounds implicated in CRC cell growth inhibitory activity.

Conclusion

Total phenolics and γ-tocotrienol were positively correlated with reduced CRC cell growth (p<0.05). Stoichiometric variation in rice bran components and differential effects on CRC viability merit further evaluation elucidate their role in dietary CRC chemoprevention.

References

Forster GM(1), Raina K, Kumar A, Kumar S, Agarwal R, Chen MH, Bauer JE, McClung AM, Ryan EP. Rice varietal differences in bioactive bran components for inhibition of colorectal cancer cell growth. Food Chem. 141(2):1545-52. Nov 15 2013. doi: 10.1016/j.foodchem.2013.04.020. Epub  2013 Apr 17. 

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