Research: ETMINAN and co-authors,

Listed in Issue 123


ETMINAN and co-authors, Division of Clinical Epidemiology, Royal Victoria Hospital and McGill University, Montreal, Quebec, Canada,, have meta-analyzed studies on antioxidant vitamins and Parkinson's disease.


The aim of the study was to examine effect of vitamin C, vitamin E, and beta-carotene on the risk of Parkinson's disease.


The relevant literature published between 1966 and 2005 was searched and a systematic review of observational studies was performed.


8 studies were identified (6 case-control, 1 cohort, and 1 cross-sectional). It was found that dietary intake of vitamin E protects against Parkinson's disease. This protective influence was een with both moderate intake (relative risk 0.81) and high intake (relative risk 0.78) of vitamin E, although the possible benefit associated with high intake of vitamin E was not significant. The studies did not suggest any protective effects associated with vitamin C or beta-carotene.


Dietary vitamin E may have a neuroprotective effect and afford some protection against Parkinson's disease. These results require confirmation in randomized controlled trials.


Etminan M, Gill SS, Samii A. Intake of vitamin E, vitamin C, and carotenoids and the risk of Parkinson's disease: a meta-analysis. Lancet Neurology 4 (6): 362-365, Jun 2005.


There are millions of sufferers of Parkinson's and other neuro-degenerative conditions. Supplementation with vitamin E appears to provide some protection against Parkinson's disease. This research needs to be replicated urgently.

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