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Research: ERGIN and ARIKAN,
Listed in Issue 90
Abstract
ERGIN and ARIKAN, University of Hacettepe, School of Health Services, Department of Microbiology and Clinical Microbiology, Ankara, Turkey, have compared two different in vitro methods for assessing the activity of tea tree oil against vaginal Candida as compared with the drug, fluconazole.
Background
The aim of the study was to test the activity of fluconazole and Melaleuca alternifolia (tea tree) oil against 99 vaginal Candida strains by two different methods.
Methodology
The broth microdilution method and the disc diffusion method were performed according to standard protocols.
Results
Fluconazole had significantly higher Minimal Inhibitory Concentrations (MICs) against two of the strains, C. krusei and C. norvegensis, than the others. Tea tree oil was found to be effective against all strains tested in concentrations ranging between 0.25% and 4% at 24 hours.
Conclusion
Tea tree oil was effective against 99 strains of vaginal Candida. Its basically unaltered effectiveness against fluconazole- resistant strains is of particular interest.
References
Ergin A, Arikan S. Comparison of microdilution and disc diffusion methods in assessing the in vitro activity of fluconazole and Melaleuca alternifolia (tea tree) oil against vaginal Candida isolates. Journal of Chemotherapy 14 (5): 465-472, Oct 2002.
Comment
In view of the increasingly difficult problems of antibiotic resistance, these results with Tea Tree ought to be widely disseminated, particularly since Tea Tree remained effective against fluconazole-resistant strains.
