Research: DONG and co-authors,

Listed in Issue 137


DONG and co-authors, Institute of BioAgricultural Sciences, Academia Sinica, Taipei, Taiwan 115, Republic of China, have developed a new method for screening herbal medicines for their pharmacological properties.

Abstract: AFTIR (after flowing through immobilized receptor) is a novel method for screening herbal extracts for pharmaceutical properties. Using AFTIR, the authors identified Cynarin in Echinacea purpurea by its selective binding to a chip immobilized receptor of T-cells, which is instrumental to immune functioning.  Cynarin’s function was verified by its ability to downregulate interleukin-2
expression in a T-cell culture line. AFTIR offers promise as an efficient screening method for herbal medicines.






Dong GC, Chuang PH, Forrest MD, Lin YC, Chen HM. Immuno-suppressive effect of blocking the CD28 signaling pathway in T-cells by an active component of Echinacea found by a novel pharmaceutical screening method. Journal of Medicinal Chemistry 49 (6): 1845-1854, Mar 23, 2006.

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