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Research: DESHMUKH and COLLEAGUES,
Listed in Issue 312
Abstract
DESHMUKH and COLLEAGUES, (1)Institute of Pharmaceutical Research, GLA University, Mathura 281406, India; (2)Delhi Institute of Pharmaceutical Sciences and Research University, Delhi 110017, India researched and developed and assessed the antiproliferative efficiency of selenium nanoparticles SeNPs-based paclitaxel delivery systems against tumour cells in vitro with relevant mechanistic visualization.
Background
Among the primary causes of mortality in today's world is cancer. Many drugs are employed to give lengthy and severe chemotherapy and radiation therapy, like nitrosoureas (Cisplatin, Oxaliplatin), Antimetabolites (5-fluorouracil, Methotrexate), Topoisomerase inhibitors (Etoposide), Mitotic inhibitors (Doxorubicin); such treatment is associated with significant adverse effects. Antitumor antibiotics have side effects similar to chemotherapy and radiotherapy.
Methodology
Selenium (Se) is an essential trace element for humans and animals, and additional Se supplementation is required, particularly for individuals deficient in Se. Due to its unique features and high bioactivities, selenium nanoparticles (SeNPs), which act as a supplement to counter Se deficiency, have recently gained worldwide attention. This study presented a safer and more economical way of preparing stable SeNPs. The researcher has assessed the antiproliferative efficiency of SeNPs-based paclitaxel delivery systems against tumour cells in vitro with relevant mechanistic visualization. SeNPs stabilized by Pluronic F-127 were synthesized and studied.
Results
The significant properties and biological activities of PTX-loaded SeNPs on cancer cells from the lungs, breasts, cervical, and colons. In one study, SeNPs were formulated using chitosan (CTS) polymer and then incorporated into CTS/citrate gel, resulting in a SeNPs-loaded chitosan/citrate complex; in another study, CTS was used in the synthesis of SeNPs and then situated into CTS/citrate gel, resulting in Se loaded nanoparticles.
Conclusion
These formulations were found to be more successful in cancer treatment. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net .
References
Deshmukh R(1), Singh R(1), Sharma S(1), Mishra AK(2), Harwansh RK(1). A Snapshot of Selenium-enclosed Nanoparticles for the Management of Cancer. Curr Pharm Des. ;30(11):841-858. doi: 10.2174/0113816128297329240305071103. 2024
