Research: DELAFUENTE, Department of

Listed in Issue 53


DELAFUENTE, Department of Pharmacy, School of Pharmacy, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA review (21 references) the use of glucosamine sulphate, a constituent of cartilage, in the treatment of osteoarthritis.




The available data suggest that glucosamine decreases pain and improves function in osteoarthritis. Most of the studies using glucosamine have methodological flaws or have used parenteral formulations, which make their data difficult to extrapolate into clinical practice. Glucosamine sulphate is shown to be as good as ibuprofen for osteoarthritis of the knee.


Better designed clinical trials of glucosamine are required in order to identify its role in the pharmacotherapy of osteoarthritis.


Delafuente JC. Glucosamine in the treatment of osteoarthritis. Rheumatic Diseases Clinics of North America 26(1): 1-11. Feb 2000.


The above group of studies is a demonstration of the wide-ranging nature of alternative approaches being clinically researched for arthritis and rheumatic diseases.

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