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Research: DA SILVA BATISTA and COLLEAGUES,
Listed in Issue 309
Abstract
DA SILVA BATISTA and COLLEAGUES, (1)Graduate Program of Health Sciences (PPGCS), Federal University of Sergipe, Aracaju, Sergipe, Brazil; (2)Nutritional Genomics Laboratory, LabGeN, School of Applied Sciences, UNICAMP, São Paulo, Brazil; (3)Nutrigenomics and Lipids Research Center, CELN, School of Applied Sciences, UNICAMP, São Paulo, Brazil; (4)Nutrition Department, Federal University of Sergipe, Lagarto, Sergipe, Brazil; (5)School of Physical Education and Sport, University of São Paulo - USP, Ribeirão Preto, São Paulo, Brazil; (6)Laboratory of Molecular Biology of Exercise, School of Applied Sciences, UNICAMP, São Paulo, Brazil; (7)Department of Physiology, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil; (8)OCRC - Obesity and Comorbidities Research Center, UNICAMP, São Paulo, Brazil conducted a review to understand ω3 fatty acid action over the inflammatory environment in the background of several chronic diseases
Background
Omega 3 (ω3) fatty acids have been described since the 1980s as promising anti-inflammatory substances. Prostaglandin and leukotriene modulation were exhaustively explored as the main reason for ω3 beneficial outcomes.
Methodology
However, during the early 2000s, after the human genome decoding advent, the nutrigenomic approaches exhibited an impressive plethora of ω3 targets, now under the molecular point of view.
Results
Different G protein-coupled receptors (GPCRs) recognizing ω3 and its derivatives appear to be responsible for blocking inflammation and insulin-sensitizing effects. A new class of ω3-derived substances, such as maresins, resolvins, and protectins, increases ω3 actions. Inflammasome disruption, the presence of GPR120 on immune cell surfaces, and intracellular crosstalk signaling mediated by PPARγ compose the last discoveries regarding the multipoint anti-inflammatory targets for this nutrient.
Conclusion
This review shows a detailed mechanistic proposal to understand ω3 fatty acid action over the inflammatory environment in the background of several chronic diseases.
References
da Silva Batista E(1)(2)(3)(4), Nakandakari SCBR(2)(3), Ramos da Silva AS(5), Pauli JR(3)(6), Pereira de Moura L(6), Ropelle ER(3)(6), Camargo EA(1)(7), Cintra DE(2)(3)(8). Omega-3 pleiad: The multipoint anti-inflammatory strategy. Crit Rev Food Sci Nutr. ;64(14):4817-4832. doi: 10.1080/10408398.2022.2146044. Epub 16 Nov 2022. . 2024,
