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Research: CRUCERIU and COLLEAGUES,
Listed in Issue 303
Abstract
CRUCERIU and COLLEAGUES, 1 1 The Oncology Institute "Prof. Dr. Ion Chiricuta," Cluj-Napoca, Romania; 2 2 "Babes-Bolyai" University, Cluj-Napoca, Romania; 3 3 University of Medicine and Pharmacy "Iuliu Hatieganu," Cluj-Napoca, Romania carried out a systematic review of the published literature to investigate the antitumor and antimetastatic effects of C officinalis and whether it might be useful in developing future novel cancer treatment strategies
Background
A continuous challenge in cancer management is to improve treatment efficacy and to diminish its side effects.
Methodology
Consequently, new conventional and unconventional drugs and bioactive compounds from plants are constantly developed, characterized, and used for in vitro and in vivo models. This review focuses on the antitumor properties of Calendula officinalis, its biological and molecular effects in tumor cells and animal models, as well as its role in cancer palliative care.
Results
A systematic review of studies describing the cytotoxic role of C officinalis and its therapeutic role on cancer cells were carried out using the PubMed database. Albeit C officinalis extracts have cytotoxic activity toward different cancer cell lines, a high grade of variation between studies was observed, depending on plant organ subjected to extraction, extraction method, and the cancer cell lines used for each study. Nevertheless, its cytotoxic activity is related to a few bioactive compounds, presenting multiple roles in both activation of proapoptotic proteins and decreasing the expression of the proteins that inhibit cell death.
Conclusion
Moreover, due to its anti-genotoxic/protective as well as antitumor and antimetastatic effects proven in animal models, C officinalis could have important future implications in developing novel cancer treatment strategies, while until now it has been used especially for diminishing the side effects of radiotherapy. Conflict of interest statement: Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
References
Daniel Cruceriu 1 2 , Ovidiu Balacescu 1 3 , Elena Rakosy 2 Calendula officinalis: Potential Roles in Cancer Treatment and Palliative Care Integr Cancer Ther. ;17(4):1068-1078. doi: 10.1177/1534735418803766. Epub Oct 5 2018 . Dec 2018.
