Research: CHIARADIA and COLLEAGUES

Listed in Issue 258

Abstract

CHIARADIA and COLLEAGUES, 1. Department of Ophthalmology, Hospital de Clínicas "José de San Martín", Universidad de Buenos Aires. 2351 Córdoba Avenue, C1120AAR, Buenos Aires. Argentina; 2. Department of Ophthalmology, University of Buenos Aires, Buenos Aires. Argentina; 3. Department of Ophthalmology, Poznan City Hospital, Poznan. Poland reviewed and described novel pharmacological and non-pharmacological treatments for Dry eye disease (DED).

Background

Dry eye disease (DED) is a multifactorial disease of the tears and ocular surface that results in symptoms such as discomfort, visual disturbance, and tear film instability, with potential damage to the ocular surface. The principal pathological mechanisms of DED are hyperosmolarity and inflammation. These mechanisms are deeply interrelated and lead to a self-perpetuating "vicious circle".

Methodology

The objective of this review is to describe novel pharmacological and non-pharmacological treatments for DED.

Results

Based on the better understanding of the physiopathology of the disease, new treatment strategies have been developed.

Conclusion

The focus of the management of DED has been taken away from just reducing symptoms and redirected towards specific targets of its physiopathology, being inflammation the most addressed topic.

References

 

Chiaradia PA1, Zeman Bardeci LA2, Dankert S2, Mendaro MO2, Grzybowski A3. Hot Topics in Dry Eye Disease. Curr Pharm Des. 23(4):608-623. doi: 10.2174/1381612822666161208094841. 2017.

Chiaradia PA1, Zeman Bardeci LA2, Dankert S2, Mendaro MO2, Grzybowski A3. Hot Topics in Dry Eye Disease. Curr Pharm Des. 23(4):608-623. doi: 10.2174/1381612822666161208094841. 2017.

 

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