Research: CARVALHO and COLLEAGUES,

Listed in Issue 270

Abstract

CARVALHO and COLLEAGUES, 1. a Brazilian National Cancer, Institute José Alencar Gomes da Silva , Rio de Janeiro , Brazil; 2. b State University of Rio de Janeiro , Rio de Janeiro , Brazil conducted a study to investigate the effect of nutritional supplementation with eicosapentaenoic acid (EPA)-enriched formula on the inflammatory profile of patients with oral cavity cancer.

Background

The objective of the study is to investigate the effect of nutritional supplementation with eicosapentaenoic acid (EPA)-enriched formula on the inflammatory profile of patients with oral cavity cancer.

Methodology

The study was conducted with 53 patients with oral cavity cancer in antineoplastic pre-treatment who were randomized into two groups: the control group received a powdered supplement without EPA during 4 weeks and the intervention group received a liquid supplement enriched with EPA (2 g/day) during the same period. In the baseline and after 4 weeks of supplementation, serum concentrations of albumin, prealbumin, C-reactive protein (CRP), and interleukin-6 (IL-6) were measured.

Results

Values of CRP and of CRP/albumin ratio were lower in the intervention group than those in the control group. However, when the two groups were compared to each other after intervention, any significant difference was not observed. There was a significant negative correlation between levels of CRP and albumin, and IL-6 and albumin, both in the control and in the intervention groups. In both groups, a positive correlation between concentrations of IL-6 and CRP was observed.

Conclusion

No significant difference was encountered in the assessed parameters between the group that received standard supplement and the group that received EPA-enriched supplement.

References

Carvalho TC1, Cruz BC1, Viana MS2, Martucci RB1, Saraiva DC1, Reis PF1. Effect of Nutritional Supplementation Enriched with Eicosapentaenoic Acid on Inflammatory Profile of Patients With Oral Cavity Cancer in Antineoplastic Pretreatment: A Controlled and Randomized Clinical Trial. Nutr Cancer: 69(3):428-435. Apr 2017. doi: 10.1080/01635581.2017.1274406. Epub Jan 27 2017.

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