Research: BAUER and COLLEAGUES,

Listed in Issue 243

Abstract

BAUER and COLLEAGUES, (1)Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California evaluated and quantified the association of antioxidant and vitamin E transport genes with risk of high-grade prostate cancer and recurrence of prostate cancer.

Background

Observational studies suggest an inverse association between vitamin E and risk of prostate cancer, particularly aggressive tumours. However, three large randomized controlled trials have reported conflicting results. The authors examined circulating vitamin E and vitamin E-related genes in relation to risk of high-grade prostate cancer and prostate cancer recurrence among men initially diagnosed with clinically organ-confined disease.

Methodology

The authors measured circulating α- and γ-tocopherol and genotyped 30 SNPs in SOD1, SOD2, SOD3, TTPA, and SEC14L2 among 573 men with organ-confined prostate cancer who underwent radical prostatectomy. They examined associations between circulating vitamin E, genotypes, and risk of high-grade prostate cancer (Gleason grade ≥ 8 or 7 with primary score ≥ 4; n = 117) using logistic regression, and risk of recurrence (56 events; 3.7 years median follow-up) using Cox proportional hazards regression.

Results

Circulating γ-tocopherol was associated with an increased risk of high-grade prostate cancer (Q4 v. Q1 odds ratio [OR] = 1.87; 95% confidence intervals [CI]: 0.97-3.58; P trend =0.02). The less common allele in SOD3 rs699473 was associated with an increased risk of high-grade disease (T > C: OR = 1.40, 95% CI: 1.04-1.89). Two independent SNPs in SOD1 were inversely associated with prostate cancer recurrence in additive models (rs17884057 hazard ratio [HR] = 0.49, 95%CI: 0.25-0.96; rs9967983 HR = 0.62, 95% CI: 0.40-0.95).

Conclusion

Among men with clinically organ-confined prostate cancer, genetic variation in SOD may be associated with risk of high-grade disease at diagnosis and disease recurrence. Circulating γ-tocopherol levels may also be associated with an increased risk of high-grade disease at diagnosis.

References

Bauer SR(1), Richman EL, Sosa E, Weinberg V, Song X, Witte JS, Carroll PR, Chan JM. Antioxidant and vitamin E transport genes and risk of high-grade prostate cancer  and prostate cancer recurrence.  Prostate 73(16):1786-95. doi: 10.1002/pros.22717. Dec 2013. Epub Aug 29 2013.

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