Research: BACCI and COLLEAGUES,

Listed in Issue 269

Abstract

BACCI and COLLEAGUES, 1. Department of Neurosciences, Section of Clinical Dentistry, University of Padova, Padova, Italy; 2. Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy conducted a randomized, double-blind, placebo-controlled crossover study to compare the efficacy of topical tocopherol acetate compared with placebo for patients with reticular oral lichen planus (ROLP).

Background

This randomized, double-blind, placebo-controlled crossover study assessed the efficacy of topical tocopherol acetate compared with placebo in easing oral discomfort in patients with reticular oral lichen planus (ROLP).

Methodology

Thirty-four patients with clinically diagnosed and histologically confirmed ROLP were randomly assigned to two groups, which received first one of two treatments (treatment 1 or 2) for a month, then the other (treatment 2 or 1) for another month, with a two-week washout between them. One treatment contained tocopherol acetate and the other only liquid paraffin. The primary outcome was less discomfort, measured on a visual analog scale (VAS). Secondary outcomes were as follows: length of striae measured and photographed at each follow-up; surface area of lesions; and a modified Thongprasom score.

Results

No statistically significant differences emerged between the two treatments (1 vs 2) in terms of VAS scores (P > 0.05; 0.8624) or length of striae (P = 0.0883). Significant differences were seen for surface area of lesions (P < 0.05, P = 0.0045) and modified Thongprasom scores (P = 0.0052).

Conclusion

The two treatments differed only in terms of the surface area of the lesions and Thongprasom scores, not in VAS scores for discomfort or the length of patients' striae. Topical tocopherol proved effective in the treatment of ROLP.

References

Bacci C1, Vanzo V1, Frigo AC1, Stellini E1, Sbricoli L1, Valente M1,2. Topical tocopherol for treatment of reticular oral lichen planus: a randomized, double-blind, crossover study. Oral Dis. 23(1):62-68. Jan 2017. doi: 10.1111/odi.12573. Epub Sep 15 2016.

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