Research: ANDERSSON and colleagues,

Listed in Issue 20


ANDERSSON and colleagues, Department of Urology, Orebro Medical Center, Sweden write that the role of diet in the aetiology of prostate cancer remains unclear because research results from several case-control and cohort studies regarding fat intake and prostate cancer risk have been inconsistent and that few studies have adjusted the data for caloric intake. The authors conducted a population-based case-control study in Sweden between 19891994 to study the relationship between energy, intake of several nutrients and prostate cancer risk.



526 patients with newly diagnosed prostate cancer and 536 controls, randomly selected from the population register and matched by age were included in the study. Dietary intake information was obtained from a self-administered semi-quantitative food frequency questionnaire.


There were positive associations of prostate cancer (all stages combined) risk with total energy intake as well as intake of total fat (saturated and monounsaturated), protein, retinol and zinc. The positive association with energy intake was stronger for advanced cancer, with an excess risk of 70% for the highest quartile vs the lowest. Following adjustment for energy intake, there was no apparent association of prostate cancers with any of the nutrients studied, although there was a weak positive association between intake of retinol and advanced cancer.


Total energy intake is a risk factor for prostate cancer.


Andersson SO et al. Energy, nutrient intake and prostate cancer risk: a population-based case-control study in Sweden. Int J Cancer 68(6): 71622. Dec 11 1996.

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