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Research: ALMUSHATAT and co-workers,
Listed in Issue 134
Abstract
ALMUSHATAT and co-workers, University Department of Surgery, Royal Infirmary, Glasgow, UK, have studied antioxidant vitamins, lipid peroxidation, and the systemic inflammatory response in patients with prostate cancer.
Background
The aim of this study was to examine the relationship between antioxidant vitamins, lipid peroxidation, disease stage and the systemic inflammatory response and patients with prostate cancer.
Methodology
14 healthy subjects, 20 patients with benign prostate hyperplasia, 40 patients with localized prostate cancer, and 38 patients with metastatic prostate cancer were enrolled in this biochemical study.
Results
Prostate cancer patients had higher concentrations of the lipid peroxidation product, malondialdehyde (p < 0.05), and lower circulating concentrations of lutein (p < 0.05), lycopene (p < 0.001) and beta-carotene (p < 0.05). Patients with metastatic prostate cancer, when compared with patients having localized disease, had lower concentrations of prostate-specific antigen (p < 0.05), vitamin E (p < or = 0.05), retinol (p < 0.01), lutein (p < 0.05) and lycopene (p < 0.01). In the prostate cancer patients, prostate-specific antigen was correlated with the concentrations of the lipid peroxidation product, malondialdehyde (rs= 0.353, p = 0.002). C-reactive protein was not correlated with the vitamin antioxidants nor malondialdehyde. In contrast, there was a negative correlation between malondialdehyde concentrations and both lutein (rs= -0.263, p = 0.020) and lycopene (rs= -0.269, p = 0.017).
Conclusion
These results indicate that lower concentrations of carotenoids, particularly lycopene (the main carotenoid in tomatoes), reflect disease progression rather than the systemic inflammatory response in patients with prostate cancer.
References
Almushatat AS, Talwar D, McArdle PA, Williamson C, Sattar N, O’Reilly DS, Underwood MA, McMillan DC. Vitamin antioxidants, lipid peroxidation and the systemic inflammatory response in patients with prostate cancer. International Journal of Cancer 118 (4): 1051-1053, Feb 15, 2006.
