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Research: AKBAR and COLLEAGUES,
Listed in Issue 308
Abstract
AKBAR and COLLEAGUES, (1)CALBINOTOX, Université de Lorraine, 54000, Nancy, France.; samina.akbar@univ-lorraine.fr. ; (2)Atta ur Rahman School of Applied Biosciences, National University of Sciences ; and Technology, Islamabad, Pakistan; (3)Faculty of Life Sciences, Institute of Home and Food Sciences, Government College University, Faisalabad, Pakistan; (4)Department of Biosciences, Faculty of Sciences, COMSATS Institute of Information Technology, Park Road, Islamabad, Pakistan.; (5)CALBINOTOX, Université de Lorraine, 54000, Nancy, France. Conducted a review of polyunsaturated fatty acids (PUFAs), notably omega-3 (n-3) and omega-6 (n-6), to obtain a better understanding of the potential risks and benefits as well as the cellular and molecular mechanisms of the basic actions of these PUFAs to explore their role as adjuvants in cancer therapy
Background
Polyunsaturated fatty acids (PUFAs), notably omega-3 (n-3) and omega-6 (n-6), have received much attention owing to their multifaceted effects not only in the management of diverse pathological conditions but also in the maintenance of overall health of an individual.
Methodology
A disproportionately high n-6 to n-3 ratio contributes to the development of various disorders including cancer, which ranks as a leading cause of death worldwide with profound social and economic burden.
Results
Epidemiological studies and clinical trials combined with the animal and cell culture models have demonstrated the beneficial effects of n-3 PUFAs in reducing the risk of various cancer types including breast, prostate and colon cancer. The anti-cancer actions of n-3 PUFAs are mainly attributed to their role in the modulation of a wide array of cellular processes including membrane dynamics, apoptosis, inflammation, angiogenesis, oxidative stress, gene expression and signal transduction pathways. On the contrary, n-6 PUFAs have been shown to exert pro-tumour actions; however, the inconsistent findings and controversial data emphasize upon the need to further investigation. Nevertheless, one of the biggest challenges in future is to optimize the n-6 to n-3 ratio despite the genetic predisposition, age, gender and disease severity. Moreover, a better understanding of the potential risks and benefits as well as the cellular and molecular mechanisms of the basic actions of these PUFAs is required to explore their role as adjuvants in cancer therapy.
Conclusion
All these aspects will be reviewed in this chapter. © 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG.
References
Akbar S(1), Rahman A(2), Ahmad N(3), Imran M(4), Hafeez Z(5). Understanding the Role of Polyunsaturated Fatty Acids in the Development and Prevention of Cancer. Cancer Treat Res.;191:57-93. doi: 10.1007/978-3-031-55622-7_3. 2024.
