Positive Health Online

A major international study has found that remotely supervised, at-home brain stimulation therapy can help patients prevent relapse after depression treatment, solving a persistent gap in long-term mental health care.

A recent study, and largest of its kind, has found that at-home brain stimulation can prevent relapse of major depressive disorder in 75% of patients. Published in the Journal of Affective Disorders, the Portable Transcranial Electrical Stimulation and Internet-Based Behavioral Therapy for Major Depression Study  (PSYLECT) study tracked the long-term effects of home-based transcranial direct current stimulation (tDCS) therapy combined with online behavioral support. The findings revealed that non-drug, at-home treatment could help many patients maintain recovery from depression over time.

In the study, participants who had completed their initial depression treatment had to use at-home brain stimulation twice a week for six months.

https://www.flowneuroscience.com/nhs-flow-pilot/

Woman using a device for at-home transcranial direct current stimulation (tDCS-based brain stimulation therapy). (Source: Flow Neuroscience)

Researchers monitored their progress to see whether the therapy could prevent relapse without ongoing clinical support. By the end of the follow-up period, only six of the 71 patients experienced a return of depressive symptoms, while 11 discontinued treatment.

The results showed that most participants maintained recovery using brain stimulation therapy alone, without the need for in-person visits or additional interventions.

As up to 85% of people with depression experience relapse during treatment, effective tools for relapse prevention are lagging.

According to the study, at-home and remotely supervised tDCS therapy can be an effective and scalable option: it achieves results comparable to in-clinic treatment, but can increase access and lower costs, as it doesn’t require clinic visits to receive therapy sessions.

“Home-based brain stimulation bridges a major treatment gap, helping patients sustain long-term recovery after antidepressants or psychotherapy,” said Erin Lee, CEO of Flow Neuroscience, the company behind a tDCS device for depression used in the study. “Many people struggle to pay for visits or travelling to the clinic, or simply are too busy to attend several sessions a week. This is when at-home therapy comes to the rescue.”

Erin Lee added that at-home tDCS-based relapse prevention can be cost-effective for clinics, too, as it reduces waiting times and frees up clinicians.

For patients, another benefit of at-home treatment is high adherence.  

“Many people with a history of depression might find it easier to stick to home-based therapy, as it’s less effort compared to regular in-clinic visits,” noted Dr Kultar Singh Garcha, a GP and Medical Director at Flow Neuroscience. “Even months into treatment, many patients still feel physically and emotionally exhausted, so lowering the effort can help them keep going.”

Beyond accessibility and scalability, researchers found at-home brain stimulation to be safe and well-tolerated, with minimal side effects like scalp itching or headaches. By the end of the study, 40% of participants reported no adverse events at all.

 The study was led by the University of São Paulo Medical School and conducted in collaboration with the Ludwig-Maximilians University in Munich, Germany, as well as the University of Ghent, Belgium, Spaulding Rehabilitation Hospital, and Massachusetts General Hospital.

Flow Neuroscience’s medical device, used in the study, is CE-certified and has regulatory approval for depression treatment in the UK, EU, Australia, Switzerland, Hong Kong, and other countries. It is backed by both clinical studies and real-world data of over 50,000 users.

By delivering gentle electrical currents to the brain, the headset regulates activity in the prefrontal cortex, the part of the brain involved in mood regulation and stress response. It is often underactive in people with depression.

“For decades, relapse has been one of the biggest challenges in depression treatment, but this is finally changing now,” said Erin Lee. “We are certain that with home-based brain stimulation therapy, effective and non-drug relapse prevention will become a new mental health care standard.”

Further Information and Media contact:

Aivaras Vilutis  aivaras.v@sensuspr.com