Research: ZIAEI and others,

Listed in Issue 119


ZIAEI and others, Department of Obstetrics and Gynaecology, Faculty of Medical Science, Tarbiat Modarres University, PO Box 14115.111, Tehran, IR, Iran, have carried out a randomized controlled trial of vitamin E in the treatment of painful periods.


The aim of the study was to investigate the effect of vitamin E on primary dysmenorrhoea (heavy and painful periods).


In this randomized, double-blinded, placebo-controlled study, 278 schoolgirls aged between 15 and 17 who suffered from primary dysmenorrhoea were given either 20 mg of vitamin E or placebo starting 2 days before the expected start of a period and continuing for 3 days after the start of the period. This treatment was carried out over 4 consecutive periods. Severity and duration of pain as well as blood loss were the primary outcome measures.


In the vitamin E group, pain severity was lower with vitamin E at two months, and drastically lower at four months (p > 0.001). Pain duration was shorter at two months and drastically shorter at four months (p > 0.0001). Blood loss was lower at two months (p > 0.0001).


Vitamin E relieves the pain of primary dysmenorrhoea and reduces blood loss.


Ziaei S, Zakeri M, Kazemnejad A. A randomised controlled trial of vitamin E in the treatment of primary dysmenorrhoea. BJOG: an International Journal of Obstetrics & Gynaecology 112 (4): 466-469, Apr 2005.


This is a result that could so easily be implemented in the primary care for women.

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