Research: TANAKA, Departments of

Listed in Issue 71


TANAKA, Departments of Obstetrics and Gynaecology, Osaka City University Medical School, Osaka, Japan, examined the therapeutic effects of several Japanese herbal medicines on menopausal symptoms induced by gonadotropin-releasing hormone (GRH) in women with endometriosis, adenomyosis or leiomyoma.




17 of the 22 patients studied showed menopausal symptoms. The following Japanese herbal remedies were administered to 13 of the 17 symptomatic patients: Toki-shakuyaku-san, Shakuyaku-kanzo-to, Keishi-bukuryo-gan, Kami-shoyo-san, Tokaku-joki-to or Keishi-to. Efficacy was observed in all 13 patients. 11 patients with hot flashes received Toki-shakuyaki-san and all experienced some relief; 4 experienced total relief. 3 patients with severe shoulder stiffness received Shakuyaku-kanzo-to and were completely relieved of symptoms. No significant changes in serum oestradiol levels were detected after treatment with the Japanese herbal medicines.


The results indicate that Japanese herbal medicines can be recommended for menopausal symptoms induced by GRH agonists without a negative effect on serum oestradiol levels.


Tanaka T. Effects of herbal medicines on menopausal symptoms induced by gonadotropin- releasing hormone agonist therapy. Clinical and Experimental Obstetrics and Gynecology 28 (1): 20-3. 2001.

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