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Research: QUILLOT and colleagues,
Listed in Issue 95
Abstract
QUILLOT and colleagues, Centre d'Investigation Clinique, Centre Hospitalo Universitaire et INSERM, France, d.quillot@chu-nancy.fr, have studied fatty acid abnormalities in chronic pancreatitis and the effect of diabetes mellitus.
Background
Patients with chronic inflammation of the pancreas suffer from malabsorption and nutritional deficiencies, giving rise to concern about their supply of essential fatty acids. However no data on fatty acid profiles in such patients are available. Diabetes, a common complication of chronic pancreatitis, could influence the fatty acid profile.
Methodology
The fatty acid composition of LDL was analyzed in the following patients: 12 men with chronic pancreatitis without diabetes; 35 men with chronic pancreatitis and diabetes secondary to this and insulin treated; 25 men with type I diabetes; and 20 healthy controls.
Results
The patients in both chronic pancreatitis groups had lower mean values for linoleic acid than controls. Monounsaturated fatty acids were elevated in these patients. Patients with chronic pancreatitis and diabetes, and patients with only diabetes, had markedly lower levels of docosahexaenoic acid and also selenium deficiency. Overall, 40% of chronic pancreatitis patients, 57.6% of chronic pancreatitis plus diabetes patients, and 13.6% of type I diabetes patients had an essential fatty acid deficiency.
Conclusion
Correction of the fundamental deficiencies in essential fatty acids seems desirable in chronic pancreatitis even if their clinical consequences have not been evaluated.
References
Quillot D. Walters E, Boehme P, Lacroix B, Bonte JP, Fruchart JC, Drouin P, Duriez P, Ziegler O. Fatty acid abnormalities in chronic pancreatitis: effect of concomitant diabetes mellitus. European Journal of Clinical Nutrition 57 (3): 496-503, Mar 2003.
Comment
These findings that a significant proportion of diabetics have essential fatty acid deficiencies would appear to be significant and ought to be the subject of further clinical research to attempt to correct this.
