Research: OBERBAUM and colleagues,

Listed in Issue 70


OBERBAUM and colleagues, The Institute of Research on Complementary Medicine, The Center of Integrated Complementary Medicine, Shaare Zedek Medical Center, P. O. Box 3235, Jerusalem 91031, Israel,, assessed the efficacy of a homeopathic remedy, TRAUMEEL S(R), in the management of chemotherapy-induced stomatitis (inflammation of the mouth) in children and young adults undergoing bone marrow transplantation .


Stomatitis is a common consequence of chemotherapy and a condition for which there is little effective treatment . The incidence of stomatitis is increasing because of more intensive treatment and is often a dose-limiting factor in chemotherapy.


32 patients aged 3-25 years who had all undergone allogeneic (n=16) or autologous (n=16) stem cell transplantation entered a randomized, placebo-controlled, double-blind clinical trial and were assigned to either placebo or TRAUMEEL S as a mouth rinse administered five times daily from 2 days after transplantation for a minimum of 14 days or until at least 2 days after all signs of stomatitis were absent . Stomatitis scores were evaluated according to the World Health Organization grading system for mucositis.


30 patients were evaluable (15 on placebo and 15 on TRAUMEEL S). 5 patients (33%) in the TRAUMEEL S group did not develop stomatitis compared with only 1 patient (7%) in the placebo group. Stomatitis worsened in only 7 patients (47%) in the TRAUMEEL S group compared with 14 patients (93%) in the placebo group. The mean area-under-the-curve (AUC) stomatitis scores were 10.4 in the TRAUMEEL S compared with 24.3 in the placebo group (p<0.01).


TRAUMEEL S may significantly reduce the severity and duration of chemotherapy-induced stomatitis in [patients] undergoing bone marrow transplantation.


Oberbaum M et al. A randomized, controlled clinical trial of the homeopathic medication TRAUMEEL S in the treatment of chemotherapy-induced stomatitis in children undergoing stem cell transplantation. Cancer 92 (3): 684-90. Aug 2001.

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