Listed in Issue 279


NAKATSU and COLLEAGUES, 1 Department of Clinical Nutrition, Graduate School of Comprehensive Rehabilitation, Osaka Prefecture University; 2 Medical Genome Center, National Center for Geriatrics and Gerontology; 3 Faculty of Nutrition, Kobe Gakuin University studied the relationship between serum vitamin E status and risk factors for arteriosclerosis in Japanese postmenopausal women;


Since vitamin E is one of the most potent antioxidant and anti-inflammatory agents, vitamin E can play a role against arteriosclerosis through various actions.


Then, we have studied the relationship between serum vitamin E status and risk factors for arteriosclerosis in Japanese postmenopausal women. One hundred and seven subjects (70.0±7.7 y) were evaluated for vitamin E status by measuring serum α- and γ-tocopherol (αT and γT) levels. The number of arteriosclerosis risk factors was defined by the existence of high blood pressure, hyperglycaemia, and dyslipidaemia.


Median serum αT and γT concentrations were 24.32 and 2.79 μmol/L, respectively. In none of the subjects, serum αT level was below the cut off value (<12 μmol/L) for vitamin E deficiency which causes fragile erythrocyte and haemolysis. While no significant differences were found in serum levels of αT and γT between the groups categorized by the number of arteriosclerosis risks, serum levels of αT adjusted by serum total cholesterol (TC) and triglyceride (TG) decreased with an increasing number of arteriosclerotic risk factors (p=0.074). Serum αT level adjusted by serum TC and TG was also a negative significant predictor for the number of arteriosclerosis risk factors controlled by covariates associated with arteriosclerosis.


The present study described that serum vitamin E level was positively associated with a lower number of arteriosclerotic risks, and its role for preventing noncommunicable diseases was suggested.


Yuka Nakatsu  1 , Shumpei Niida  2 , Kiyoshi Tanaka  3 , Shigeo Takenaka  1 , Akiko Kuwabara  1. The Relationship between Serum Vitamin E Level and Risk Factors for Arteriosclerosis in Japanese Postmenopausal Women J Nutr Sci Vitaminol (Tokyo) ;66(3): 213-218. doi: 10.3177/jnsv.66.213. 2020.


The above research demonstrated that serum vitamin E was positively associated with decreased arteriosclerotic  risks and suggested its preventive role in noncommunicable disease. 

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