Research: LANDMARK,

Listed in Issue 133


LANDMARK, Institutt for farmakoterapi, Det medisinske fakultet, Universitetet i Oslo, Postboks 1065 Blindern, 0316 Oslo, Norway, has reviewed (39 references) the development of Alzheimer’s and vitamins C and E.


Alzheimer’s dementia is a neurodegenerative disease characterized by loss of memory and other cognitive functions. Oxidative stress is a possible pathogenic factor and the antioxidant vitamins C and E could therefore have a beneficial effect.


The relevant literature (several observational studies and two clinical controlled trials) describing effects of vitamin C and E in Alzheimer dementia were evaluated.


Several observational studies in mostly healthy, elderly individuals have indicated that vitamin C and E, mainly from food as well as the combination of high doses of the same vitamins, may have a beneficial effect on the development of Alzheimer’s disease. One controlled clinical trial in patients with manifest Alzheimer dementia, in which vitamin E 2000 mg/day was given as the only vitamin, has to a certain extent confirmed these results.


A causal relationship between intake of the vitamins and Alzheimer dementia has not been clarified. The correct dosages are not known, but a diet rich in antioxidant vitamins could probably reduce the risk of dementia.


Landmark, K. Could intake of vitamins C and E inhibit development of Alzheimer dementia? Tidsskrift for Den Norske Laegeforening 126 (2): 159-161, Jan 12, 2006.      


This is a potentially important result which could have significant results to large number of ageing individuals in western countries.

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