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Research: DE STEFANI and colleagues
Listed in Issue 34
Abstract
DE STEFANI and colleagues, Registro Nacional de Cancer, Montevideo, Uruguay conducted a case-control study between 1994-96 to investigate the relationship between the frequency of intake of different types of fat and breast cancer .
Background
Methodology
There were 365 breast cancer cases and 397 control women.
Results
There was a moderate and non-significant increase in the risk of breast cancer associated with total fat intake. Saturated and mono-unsaturated fat intake were not associated with an increased risk of breast cancer; however polyunsaturated fat and linoleic acid were associated with a significantly reduced risk . On the contrary, both alpha-linolenic acid and cholesterol intakes were associated with increased risk of breast cancer (Odds Ratio (OR) for upper quartile of alpha-linolenic acid intake = 3.79). When alpha-linolenic was evaluated at differing intake levels, ORs were significantly higher at low levels of linoleic acid intake (OR = 7.5).
Conclusion
References
De Stefani et al. Essential fatty acids and breast cancer: a case-control study in Uruguay. Int J Cancer 76(4): 491-4 May 18 1998.
