Research: CLAUSEN and colleagues

Listed in Issue 71


CLAUSEN and colleagues, Department of Obstetrics and Gynecology, Aker University Hospital, Oslo, Norway,, investigated whether diet in the first half of pregnancy is associated with the risk for pre-eclampsia.


Pre-eclampsia is associated with high body mass index (BMI), insulin resistance and hypertriglyceridaemia.


In this prospective, population-based, cohort study, 3,133 women (83% response rate) completed a quantitative food frequency questionnaire investigating their dietary intake early in the second trimester of pregnancy.


85 of the women developed pre-eclampsia. The adjusted odds ratio (OR) for pre-eclampsia was 3.7 (95% confidence interval [CI], 1.5-8.9) for energy intake of >3,350 kcal/day compared with 2,000 kcal/day. The adjusted OR for pre-eclampsia was 3.6 (95% CI, 1.3-9.8) for sucrose intake (% of total energy) of >25% compared with 8.5%, and was 2.6 (95% CI, 1.3-5.4) for polyunsaturated fatty acids (PUFAs) intake (% of total energy) of >7.5% compared with 5.2%. Other energy-providing nutrients were not associated with the risk for pre-eclampsia.


The findings suggest that high intakes of energy, sucrose and PUFAs independently increase the risk for pre-eclampsia.


Clausen T et al. High intake of energy, sucrose, and polyunsaturated fatty acids is associated with increased risk of preeclampsia. American Journal of Obstetrics and Gynecology 185 (2): 451-8. Aug 2001.

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