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Research: BUNGAU and COLLEAGUES,
Listed in Issue 282
Abstract
BUNGAU and COLLEAGUES, 1 Pharmacy Department, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania; 2 Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt; 3 Department of Ophthalmology and Micro-technology, Yokohama City University, Yokohama, Japan; 4 Faculty of Medicine, Al-Azhar University, Cairo, Egypt conducted a review to discuss the role and mechanisms of polyphenols and carotenoids and their possible synergistic effects on the prevention and treatment of age-related eye diseases that are induced or augmented by oxidative stress and inflammation.
Background
Oxidative stress and inflammation play a critical role in the initiation and progression of age-related ocular abnormalities as cataract, glaucoma, diabetic retinopathy, and macular degeneration. Therefore, phytochemicals with proven antioxidant and anti-inflammatory activities, such as carotenoids and polyphenols, could be of benefit in these diseases.
Methodology
The authors searched PubMed and Web of Science databases for original studies investigating the benefits of different carotenoids and polyphenols in age-related ophthalmic diseases.
Results
Our results showed that several polyphenols (such as anthocyanins, Ginkgo biloba, quercetin, and resveratrol) and carotenoids (such as lutein, zeaxanthin, and mesoxanthin) have shown significant preventive and therapeutic benefits against the aforementioned conditions. The involved mechanisms in these findings include mitigating the production of reactive oxygen species, inhibiting the tumour necrosis factor-α and vascular endothelial growth factor pathways, suppressing p53-dependent apoptosis, and suppressing the production of inflammatory markers, such as interleukin- (IL-) 8, IL-6, IL-1a, and endothelial leucocyte adhesion molecule-1.
Conclusion
Consumption of products containing these phytochemicals may be protective against these diseases; however, adequate human data are lacking. This review discusses the role and mechanisms of polyphenols and carotenoids and their possible synergistic effects on the prevention and treatment of age-related eye diseases that are induced or augmented by oxidative stress and inflammation.
References
Simona Bungau 1 , Mohamed M Abdel-Daim 2 3 , Delia Mirela Tit 1 , Esraa Ghanem 4 , Shimpei Sato 3 , Maiko Maruyama-Inoue 3 , Shin Yamane 3 , Kazuaki Kadonosono 3. Health Benefits of Polyphenols and Carotenoids in Age-Related Eye Diseases. Oxid Med Cell Longev;2019:9783429. Feb 12 2019. doi: 10.1155/2019/9783429. eCollection 2019.
