Listed in Issue 283


AHMAD and COLLEAGUES, 1 Department of Pharmaceutics, College of Pharmacy, Najran University, Najran, 61441, Kingdom of Saudi Arabia; 2 Nanomedicine Research Lab, Faculty of Pharmacy, Jamia Hamdard, New Delhi, 110062, India; 3 Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, Taif-Al-Haweiah, 21974, Kingdom of Saudi Arabia; 4 Department of Pharmacology, College of Pharmacy, Najran University, Najran, 61441, Kingdom of Saudi Arabia; 5 Department of Pharmacology, College of Medicine, Assiut University, Assiut, 71526, Egypt; 6 Le Studium Loire Valley Institute for Advanced Studies, Centre-Val de Loire region, Orleans, 45100, France; 7 Narayan Institute of Pharmacy, Gopal Narayan Singh University, Jamuhar-Sasaram, Bihar, 821305, India conducted a review providing an overview of potential therapeutic activities of ω-3-PUFAs.


Omega-3 polyunsaturated fatty acids (ω-3-PUFAs) are dietary components that have been extensively recognized for their therapeutic value and have shown diverse therapeutic effects including anti-inflammatory, antiarrhythmic, antithrombotic, immunomodulatory and antineoplastic activities.


Most of the ω-3-PUFAs are obtained through diet or supplements because the body does not synthesize them. The high instability of ω-3-PUFAs to oxidative deterioration, lower bioavailability at the target tissues and reduced bioactivity of ω-3-PUFAs is an impediment for achieving their therapeutic potential.


The present review provides an overview of potential therapeutic activities of ω-3-PUFAs and different novel technical approaches based on nanotechnology, which have been emphasized to overcome instability problems as well as enhance the bioactivity of ω-3-PUFAs.


Future prospects related to this area of research are also provided.


Mohammad Zaki Ahmad  1 , Javed Ahmad  1 , Sobiya Zafar  2 , Musarrat Husain Warsi  3 , Basel A Abdel-Wahab  4   5 , Sohail Akhter  2   6 , Md Afroze Alam  7. Omega-3 fatty acids as adjunctive therapeutics: prospective of nanoparticles in its formulation development. Ther Deliv;11 (1):851-868. Epub Dec 16 2019. doi: 10.4155/tde-2019-0072.  Jan 2020.

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